A protease draws first blood
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A protease draws first blood
8 intact protein antigens. But, presumably, lysosomal proteases must work in concert to deliver a carefully orchestrated series of cuts if the correct peptide is to be generated. Antigen-presenting cells from knockout mice lacking cathepsins D, B or L show no obvious defects in antigen presentation, indicating that other proteases are involved in both removing Ii and converting the antigen into...
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ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/25238